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KMID : 1140120120170020169
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Cancer Prevention Research
2012 Volume.17 No. 2 p.169 ~ p.175
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Effect of Hizikia fusiforme Extracts on Serum Lipid Profile and Anti-inflammatory Effects of the Rat
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Kim Hyang-Suk
Choi Eun-Ok
Park Cheol
Choi Yung-Hyun
Chung Kyung-Tae
Hwang Hye-Jin
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Abstract
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The purpose of this study was to investigate the serum lipid profile and anti-inflammatory effects of Hizikia fusiforme according to the various extracts in Sprague-Dawley rat. Experimental group was divided into 6 groups: a control group (C), H. fusiforme ethanol extract group (EtOH), H. fusiforme dichloromethane fraction group (CH2Cl2), H. fusiforme ethylacetate fraction group (EtOAc), H. fusiforme butanol fraction group (n-BuOH), H. fusiforme water fraction group (H2O), respectively. H. fusiforme extracts (400 mg/kg B.W) were orally administrated into rat every day for 4 weeks. The triglyceride concentrations were significantly decreased in CH2Cl2, n-BuOH and H2O group compared to the control group (p＜0.05). The HDL-cholesterol levels of the EtOH and H2O group were significantly higher than the control group (p＜0.05). In the muscle tissue, the expression of iNOS was decreased in CH2Cl2 (39%) and EtOAc (28%) group compare to control group. The expression of COX-2 in the liver was inhibited in the CH2Cl2 (60%) and n-BuOH (48%) group compared to control group. In the muscle tissue, the expression of COX-2 were inhibited in the n-BuOH and H2O group (33% and 58%) compared to control group. It was found from the results suggest that H. fusiforme extract could be effective on serum lipid profile and expression of anti-inflammatory mediators.
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KEYWORD
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Hizikia fusiforme, lipid profile, iNOS, COX-2
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